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of which are coordinated by a shared amino-acid residue. Coordination sites are widely spaced on the protein, and the zinc may be used for both structural and catalytic functions. In addition to these three groups, zinc has also been found to serve a bridging function between two separate polypeptides to stabilize a biologically active larger complex (e.g., nitric oxide synthase). A selection of zinc enzymes is included in Table 2, which helps to illustrate the wide variety of metabolic functions requiring zinc.

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