Info

aEnrichment = 103 (RRsample - 1Y

V-SMOW, Vienna Standard Mean Ocean Water.

aEnrichment = 103 (RRsample - 1Y

V-SMOW, Vienna Standard Mean Ocean Water.

with carbon dioxide with exchange of oxygen between the water and carbon dioxide. This procedure is also automated.

Single Pool Kinetics

Considering only hydrogen, Figure 1 represents a subject, in water balance, with a total body water of N mol with water (tracee) input and output rates of F mol/day containing 2H at a naturally abundant molar concentration, Cb. A fractional output or rate constant is defined as K = F/N.

If a small quantity (D mol) of water labeled with 2H tracer is added to the pool, it will be removed from it according to the monoexponential relationship qt - qb = De

-Kt where D is the amount of tracer given, qt is the total amount (mol) in the body pool at time t (days), and qb is the amount always present due to inflow at natural abundance. K is a fractional rate constant, sometimes defined in terms of the biological half-life T1/2. This can be calculated as T1/2 = ln2/K = 0.693/K.

Since input and output rates are the same and the amount of tracer added is small relative to the pool size, we can write qt - qb

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