Removal of potentially harmful peroxides and modulation of eicosanoid synthesis

Type I


>50% of total Se in body; acts as Se buffer/store

Type II


May protect the intestine

Type III


Found in plasma and milk; synthesized in kidney

Type IV


Phospholipid hydroperoxide GPx; abundant in testis; resistant to Se deficiency; involved in eicosanoid metabolism

Thioredoxin reductases

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