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Figure 4 illustrates some aspects of total imprecision and the origins of the variance for a typical subject defined in Table 3 when different dosing regimes are applied, with 18o enrichment being varied at a constant initial 2H:18O ratio of 8.

The following are general considerations:

1. Naturally occurring covariance in 2H and 18O enrichment in baseline samples can be used to mitigate errors resulting from physiological variation in these values if dose sizes are suitably tailored to the slope of the variation. Optimum doses in this respect are predicted by

optimal where (2H/18O)optimal is the ratio of immediate postdose - background enrichments (rel V-SMOW) for

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