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have not been fully determined. In addition, we do not know all the details of the regulation of gene expression. Some genes have been intensely studied, whereas others have yet to be identified. In contrast, the genome in the mitochondria has been completely sequenced and mapped. It is a very small genome encoding only 13 gene products (components of the mitochondrial respiratory chain) under the control of a single promoter sequence, the D-loop. Despite its small size and apparent simplicity, however, we know even less about the regulation of its expression than we know about some of the nuclear-encoded genes.

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