Lipoproteins

I J M Ordovas, Tufts University, Boston, MA, USA

© 2005 Elsevier Ltd. All rights reserved.

Cholesterol and triacylglycerol are transported in blood as lipoproteins. Lipoproteins are generally spherical particles, with a surface layer composed of phospholipid with the fatty acids oriented toward the core of the particle. Included in this phospholi-pid layer are specific proteins known as apolipopro-teins and free cholesterol. The core of the lipoprotein particles is made up of cholesteryl ester and triacyl-glycerol molecules.

The classification of serum lipoproteins has evolved historically through several phases corresponding with the development of different laboratory methodologies, including electrophoretic, ultra-centrifugal, and immunological techniques. By using these techniques, lipoproteins can be classified based on their electr-ophoretic mobility, hydrated density, and protein content.

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