Local regulation of bone cell proliferation maturation and function by polypeptide growth factors

A variety of growth factors (e.g., fibroblast growth factor and IGF-I) stimulate the division of preosteo-blastic cells. Other signal molecules (e.g., transforming growth factor ft) are associated with developmental events such as the formation of the vertebrae, jaws, and palate. Osteoblasts produce many of these growth factors themselves and deposit them in their extracellular matrix, suggesting that they coordinate small groups of cells at specific locations. Osteoclast recruitment is regulated by a variety of blood cell growth factors, termed 'colony stimulating factors'. Several of these are produced by osteoblastic cells. Osteoblasts have also been shown to produce factors that stimulate mature osteoclasts to resorb.

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