Management

Insufficient controlled clinical trials have been performed to make clear-cut recommendations for pharmacotherapy for toxicity from either nickel or bismuth. Diethyl dithiocarbamide chelation therapy when promptly administered intravenously has been reported to be effective in acute nickel carbonyl poisoning. In addition, there have been anecdotal case reports of the reversal of myoclonic encephalo-pathy caused by bismuth with use of dimercaprol. However, no recommendations can be given at the present time.

See also: Ascorbic Acid: Physiology, Dietary Sources and Requirements; Deficiency States. Food Safety: Other Contaminants. Vitamin D: Physiology, Dietary Sources and Requirements.

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