Mitochondrial Fatty Acid bOxidation

To recover their stored energy, fatty acids must be oxidized. Quantitatively, the most important energy-yielding degradation pathway is mitochon-drial ^-oxidation (Figure 2). Fatty acids must first enter cells or tissues. Serum triacylglycerol, usually associated with lipoproteins, is hydrolyzed by lipoprotein lipase located on the capillary endothe-lium, releasing fatty acids for cellular uptake. In addition, albumin-bound circulating free fatty acids (e.g., produced by the mobilization of adipo-cyte fat stores) reach the cell surface. Although

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