No Pai1

PGI2 & PGF2„ Resistin TNF-a VEGF

Plays a protective role in the pathogenesis of type 2 diabetes and cardiovascular diseases

Possible link between the complement pathway and adipose tissue metabolism Precursor of angiotensin II; regulator of blood pressure and electrolyte homeostasis Influences the rate of triacylglycerol synthesis in adipose tissue

Oxidized in tissues to produce local energy. Serve as a substrate for triglyceride and structural molecules synthesis. Involved in the development of insulin resistance Structural component of the major classes of biological lipids and gluconeogenic precursor Stimulates proliferation of a wide variety of cells and mediates many of the effects of growth hormone

Implicated in host defense, glucose and lipid metabolism, and regulation of body weight Signals to the brain about body fat stores. Regulation of appetite and energy expenditure. Wide variety of physiological functions Important regulator of vascular tone. Pleiotropic involvement in pathophysiological conditions Potent inhibitor of the fibrinolytic system

Implicated in regulatory functions such as inflammation and blood clotting, ovulation, menstruation, and acid secretion Putative role in insulin resistance May participate in inflammation

Interferes with insulin receptor signaling and is a possible cause of the development of insulin resistance in obesity Stimulation of angiogenesis

Vasoactive factors

Lipid metabolism

Immune response

Angiotensinogen Monobutyrin Adiponectin PAI-1

Eicosanoids VEGF

Tissue factor Nitric oxide

Binding proteins

Vasoactive factors

Lipid metabolism

Angiotensinogen Monobutyrin Adiponectin PAI-1

Eicosanoids VEGF

Tissue factor Nitric oxide

Binding proteins

Retinol

Adipsin ASP

Factors B and C3 CSFs IL-17 D SAA3

Growth factors

TGF/3 IGF-1 HGF NGF

Lysophosp hatidic acid

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