NSAIDinduced Ulcers

NSAID-induced ulcers are more commonly gastric ulcers. The prevalence of ulcers is more than 15% among chronic NSAID users and less than 4% among those using NSAIDs for less than 1 year. Gastritis or H. pylori infection is not a prerequisite for NSAID-induced ulcers. The damaging effect of NSAIDs is thought to be due to their effect on pros-taglandin synthesis. Endogenous prostaglandin aid in maintaining gastric mucosal blood flow and epithelial integrity and promote epithelial regeneration. NSAIDs reduce prostaglandin synthesis thus reducing the effect of prostaglandin in mucosal defense.

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