Nutritional intervention is associated with better growth and improvement or stabilization of pulmonary function and possibly may improve survival in CF. Malnutrition has several adverse effects, including poor growth, impaired muscle function, decreased exercise tolerance, increased susceptibility to infection, and decreased ventilatory drive. Studies indicate that BMI strongly correlates with lung function, but the exact mechanism of this relationship has not been fully determined. Achieving optimum nutrition and growth may minimize the progressive decline in pulmonary function commonly seen in CF. As early as the 1970s, the Toronto CF clinic was able to show that a high-fat diet promoted a normal growth pattern and improved survival.
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