O

and ALA to EPA and DHA. This conversion was shown by using deuterated ALA. There is competition between n-6 and n-3 fatty acids for the desaturation enzymes. However, both A-4 and A-6 desaturases prefer n-3 to n-6 fatty acids. But a high LA intake interferes with the desaturation and elongation of ALA. Trans-fatty acids interfere with the desaturation and elongation of both LA and ALA.

Table 1 Polyunsaturated oils high in n-6 and n-3 fatty acids

n-6 oils

n-3 oils

Corn oil

Fish oil

Safflower oil

Chia oil

Sunflower seed oil

Perilla oil

Cottonseed oil

Flaxseed oil

Soybean oil

Canola oil

Peanut oil

Walnut oil

Sesame oil

Soybean oila

Grapeseed oil

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