Nicotinamide adenine (F) dinucleotide (NAD+)

Figure 2 Structural relationship of vitamin-coenzyme for (A) thiamine (B^, (C) riboflavin (B2), and (E) niacin. In the left column is the structure of the vitamin, in the right column the coenzyme derived from the vitamin. Note the pyrophosphate group in the coenzyme derived from thiamine (B) and the prevalence of phosphate and adenyl groups in the coenzymes derived from riboflavin (D) and niacin (F), showing the necessity for ATP in their synthesis.

enzymes. The flavin cofactor is bound covalently to the structure preventing disengagement during purification procedures.

Reactions Flavin enzymes are designed to remove (and add) electrons to and from substrates. In general, flavin coenzymes are stronger oxidizing agents than the pyrimidine coenzymes (NAD+, NADP+) and tend to participate in more complex reactions. Also, flavin coenzymes can accept single electrons from a donor, forming a semiquinone and allowing flavoproteins to take part in reactions that form free radicals. Having a single electron also allows favins to bind molecular oxygen as a hydroperoxyl complex.

Was this article helpful?

0 0
Diabetes Sustenance

Diabetes Sustenance

Get All The Support And Guidance You Need To Be A Success At Dealing With Diabetes The Healthy Way. This Book Is One Of The Most Valuable Resources In The World When It Comes To Learning How Nutritional Supplements Can Control Sugar Levels.

Get My Free Ebook

Post a comment