Sex-hormone status and the pubertal growth spurt are important in determining bone mass at maturity. Conversely, bone loss accelerates in the first years after the menopause as the skeleton adapts to declining oestrogen levels. In general, postmenopau-sal women who lose bone fastest have the lowest endogenous sex-hormone levels. Although the skeletal role of oestrogens at the cellular level remains unclear, recent findings suggest that oestrogens may have a direct effect on osteoblastic cells.

Growth and Development, Physiological Aspects. Osteoporosis. Vitamin A: Physiology. Vitamin D:

Physiology, Dietary Sources and Requirements; Rickets and Osteomalacia.

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