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Figure 4 A schematic representation of the origin of vitamin D3 and its metabolism in the liver by the hepatic vitamin D-25-hydroxylase. Once formed, the 25-hydroxyvitamin D3 (25(OH)D3) is metabolized by either a 25(OH)D-1a-hydroxylase or a 25(OH)D-24-hydroxylase. 1,25-Dihydroxyvitamin D3 (1,25(OH)2D3) can either go to its target tissues to carry out its biologic function(s), or it can be metabolized in its side-chain and degraded to calcitroic acid. (Reproduced with permission from Holick MF (1995) Vitamin D: Photobiology, Metabolism, and Clinical Applications. In: DeGroot LJ et al. (eds.) Endocrinology, 3rd edn, pp. 990-1013. Philadelphia: W.B. Saunders.)

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