Other Nutrients

As noted previously, nutritional factors may be involved in the aetiology of some of the nonfolate-related NTDs. Although there is increasing evidence for the involvement of vitamin B12 and less evidence for vitamin C, riboflavin, and zinc, the available evidence is not strong enough to support dietary supplementation with these or other nutrients.

Because large doses of vitamin A are known to be teratogenic, women at risk of pregnancy and those in the early months of pregnancy should avoid liver products which can contain high quantities of vitamin A. In order to keep daily vitamin A intake below 10 000IU, women in these groups should not take a multivitamin tablet that contains a dose of more than 5000IU.

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