Pred

NS FU: 2/24 TEN 10/27 (P = 0.04)

8 dropouts in TEN; equal improvements of albumin, Child score, Maddrey score; equal rate of infections

aGalambos JT, Hersh T, Fulenwider JT et al. (1979) Hyperalimentation in alcoholic hepatitis. American Journal of Gastroenterology 72: 535-541.

^Mendenhall CL, Bongiovanni G, Goldberg S et al. (1985) VA cooperative study on alcoholic hepatitis. Ill: Changes in protein-calorie malnutrition associated with 30 days of hospitalization with and without enteral nutritional therapy. Journal of Parenteral and Enteral Nutrition 9: 590-596.

cCalvey H, Davis M, and Williams R (1985) Controlled trial of nutritional supplementation, with and without branched chain amino acids enrichment, in treatment of acute alcoholic hepatitis. Journal of HepatologyV. 141-151.

dSoberon S, Pauley MP, Duplantier R et al. (1987) Metabolic effects of enteral formula feeding in alcoholic hepatitis. Hepatology 7: 1204-1209.

"Cabré E, Rodriguez-lglesias P, Caballería J et al. (2000) Short-term and long-term outcome of severe alcohol-induced hepatitis treated with steroids or enteral nutrition: A multicenter randomized trial. Hepatology 32: 36-42.

AA, amino acids; BCAA, branched-chain amino acid; FU, follow-up; NS, not significant; PRED, prednisolone group; TEN, total enteral nutrition group.

From Stickel F, Hoehn B, Schuppan D, and Seitz HK (2003) Review article: Nutritional therapy in alcoholic liver disease. Alimentary Pharmacology & Therapeutics 18: 357-373.

Table 2 Studies on treating alcoholic cirrhosis with oral and enteral nutritional therapy®

Reference

Design

Patients Duration Experimental treatment (No.) (days) (EXP)

Smith et al.

(1982)a

Keohane et al.

McGhee et al. (1983)c

Christie et al. (1985)d

Okita et al.

(1985)e Bunout et al.

(1989)f Cabre et al.

Hirsch et al. (1993/

Open label

Open label

Randomized, double-blind, crossover Randomized, double-blind, crossover Open label

Randomized, controlled Randomized, controlled Randomized

Randomized

Randomized, controlled

Open label

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