Primary Causes and Abnormalities of Rickets and Osteomalacia

The primary cause of rickets and osteomalacia is vitamin D deficiency and the clinical characteristics of these diseases depend on age at onset. The biochemical patterns of too low a serum concentration of 25(OH)D3, however, remain quite similar (Table 2) even though the structural effects on the skeleton differ. One common microscopic feature of

Table 2 Characteristic clinical features and blood serum measurements in rickets and osteomalacia

Age

Clinical features

Blood serum measurements

Children

Skeletal deformations

Hypocalcemia

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