Protein Oxidation and Damage

There are fewer data on the role that flavonoids may play on protecting protein from oxidative damage, and as with protection of DNA from oxidation, results of studies on their effect are not consistent. Quercetin provided from black current and apple juice increases the concentration of plasma 2-amnio-adipic semialdehyde residues (a marker of protein oxidation), and the increase in concentration of these semialdehyde residues increases with increasing intake of quercetin. These results suggest a prooxidant effect of the diet on protein (there was no effect on total antioxidant capacity and a decrease in lipid oxidation). However, consumption of grape seed extract (three times per day for 1 week) does not affect plasma 2-amnio-adipic semialdehyde concentration. Moreover, consumption of a green tea extract does not alter hemoglobin protein oxidation.

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