Quality Control

Safety of PN solutions is a paramount objective and includes ensuring accuracy in compounding and avoiding both particulate matter and microbial contamination. PN solutions must be prepared using a strict aseptic technique in a class 100 environment using a laminar flow hood. All PN additives should always be added in the sterile environment to prevent risk of contamination. Many incompatibility issues exist when considering mixtures of PN solutions with other medications. Practitioners should assume that medications are incompatible unless data otherwise prove compatibility exists. Some medications have been demonstrated to be compatible as a component of PN solutions, such as heparin, regular insulin, H2-receptor antagonists, and corticosteroids.

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