Quantity of Food

The quantity of cow's milk, for example, required to produce an allergic reaction varies from patient to patient. Some patients are highly sensitive and develop anaphylaxis after ingestion of less than

1 mg of casein, ^-lactoglobulin, or a-lactalbumin. In contrast, there are children and adults who do not react to 100 ml of milk but who do react to 200 ml or more. There is a relationship between the quantity of milk required and the time of onset of symptoms. In one study, the median reaction onset time in those who reacted to 100-ml milk challenges was

2 h, but the median reaction onset time in those who required larger amounts of milk to elicit reactions was 24 h.

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