Figure 5 Peroxisomal phytanic acid a-oxidation pathway. The dietary 3-methyl-branched fatty acid phytanic acid is toxic if allowed to accumulate in the tissues. Its 3-methyl group prevents degradation by ^-oxidation; therefore, this fatty acid is first shortened by one carbon atom. Like the substrates for peroxisomal ^-oxidation, phytanic acid enters peroxisomes by an unknown mechanism. Activated phytanic acid is hydroxylated on carbon 2. Cleavage between carbons 1 and 2 yields a one-carbon CoA compound, formyl-CoA, and an aldehyde, pristanal. After oxidation and reactivation to the CoA derivative, pristanoyl-CoA can be degraded by ^-oxidation.

dicarboxylic acids can then be at least partially degraded by ^-oxidation from the !-end, primarily in peroxisomes.

Gaining Weight 101

Gaining Weight 101

Find out why long exhausting workouts may do more harm than good. Most of the body-building workout and diet regimens out there are designed for the guys that gain muscle and fat easily. They focus on eating less and working out more in order to cut the excess fat from their bodies while adding needed muscle tone.

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