Renal and Urogenital System

That renal creatinine and inulin clearance decreases with aging has been demonstrated for decades. These functional changes in filtration are associated with changes in the glomerular structure in the kidney. Circulatory senescence decreases blood flow to the kidneys, which further reduces the efficiency of renal clearance. The reserve capacity of these organs is such, however, that age-associated glomerular decline per se does not compromise the net excretion of nitrogenous waste.

Urine flow at the outlet is another aging consideration. The male urogenital system undergoes a characteristic aging change in the hypertrophy of the prostate gland, associated with decreased secretion of prostatic fluid. The anatomical consequence is a constriction in the passage through which urine flows from the bladder.

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