The Body Glucose Pool

The body of an adult subject seldom contains less than 8g, or more than 28 g, of glucose at any one time (corresponding to blood glucose concentrations of 3.5-10 mmoll-1), despite enormous fluctuations in demand and supply. This quantity of glucose can be considered as constituting a hypothetical body pool (Figure 1) confined within a glucose space equal in volume to the combined water in blood and the interstitial fluid (i.e., approximately 35% of total body water).

Glucose enters the cells by facilitated transport utilizing one or more of the genetically determined glucose transporter proteins that have been identified, depending on the tissue and which proteins are inducible. Upon entering a cell, glucose is immediately phosphorylated and consequently removed from the glucose pool.

Although its subsequent conversion into carbon dioxide and water or other metabolites (most notably glycogen, glycerol, fatty acids, and the glyco-moieties of mucopolysaccharides and glycoproteins) is the only way that glucose ordinarily leaves the glucose pool, its loss in the urine may become a major factor in diabetes mellitus. Glucose enters the glucose pool from food in the intestine after a meal via the portal vein or, in the postabsorptive subject, by release of glucose from preformed glycogen or molecules newly synthesized by liver cells into the hepatic veins.

Supplements For Diabetics

Supplements For Diabetics

All you need is a proper diet of fresh fruits and vegetables and get plenty of exercise and you'll be fine. Ever heard those words from your doctor? If that's all heshe recommends then you're missing out an important ingredient for health that he's not telling you. Fact is that you can adhere to the strictest diet, watch everything you eat and get the exercise of amarathon runner and still come down with diabetic complications. Diet, exercise and standard drug treatments simply aren't enough to help keep your diabetes under control.

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