The Gut Associated Lymphoid Tissue GALT

The complex function of the gut-associated lymphoid tissue (GALT) is the critical protective immune system in the GI tract. Peyer's patches are cells found in the mucosa and submucosa of the small intestine and contain CD4, CD8 T cells and B cells. M cells that overlay the epithelium transport antigens to the Peyer's patches that initiate the adaptive immune response. Production of secretory IgA occurs and other immune cells then enter systemi-cally through the Peyer's patches and into the mesenteric lymph system. IgA cells prevent pathogens from adhering to the intestinal surface thus preventing gut cell damage.

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