High intakes of thiamin administered orally are nontoxic. The rapidly saturable thiamin absorption mechanism limits the amount taken up from a single dose to ^2.5 mg, and thiamin present in excess of protein binding capacity is excreted. However, there are reports of toxicity from chronic intakes in excess of 50mg/kg or >3 g/day with a wide variety of clinical signs, including headache, irritability, insomnia, rapid pulse, weakness, rapid pulse contact dermatitis, pruritus, and, in one case, death.

See also: Alcohol: Disease Risk and Beneficial Effects. Carbohydrates: Regulation of Metabolism. Cereal Grains. Drug-Nutrient Interactions. Thiamin: Beriberi.

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