Chronic intakes in excess of 50 mg/kg, or more than 3 g/day, are toxic to adults with a wide variety of clinical signs, including headache, irritability, insomnia, rapid pulse, weakness, contact dermatitis, pruritis, and, in one case, death. Early researchers also indicated that regular administration or contact with thiamin occasionally led to allergic response, contact dermatitis, or hypersensitivity.

See also: Alcohol: Effects of Consumption on Diet and Nutritional Status. Cereal Grains. Fish. Thiamin: Physiology.

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