Transport of Biotin into Human Milk

More than 95% of the biotin in human milk is free in the skim fraction. The concentration of biotin varies substantially in some women and exceeds the concentration in serum by one or two orders of magnitude, suggesting that there is a system for transport into milk. Metabolites account for more than half of the total biotin plus metabolites in early and transitional human milk. With postpartum maturation, the biotin concentration increases, but inactive metabolites still account for approximately one-third of the total biotin plus metabolites at 5 weeks postpartum. Studies have not detected a soluble biotin binding protein.

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