2.4 (61) 3.0 (77) 3.3 (85) 3.6 (92) 4.3 (110) Median Potassium Intake [gm (mmol)/d] of Quintile *P-trend = 0.007

Figure 2 Relative risk of ischemic stroke by quintile of potassium intake in 43738 men. (Data, from Ascherio A, Rimm EB, Hernan MA et al. (1998) Intake of potassium, magnesium, calcium, and fiber and risk of stroke among U.S. men. Circulation 98: 1198-1204.)

readily excreted in the urine. In contrast, supplemental potassium can lead to acute toxicity in healthy individuals. Also, in individuals whose urinary potassium excretion is impaire a potassium intake less than 4.7g/day (120 mmol/day) is appropriate because of adverse cardiac effects (arrhythmias) from hyperkalemia. Drugs that commonly impair potassium excretion are angiotensin converting enzyme inhibitors, angiotensin receptor blockers, and potassium-sparing diuretics. Common medical conditions associated with impaired potassium excretion are diabetes, chronic renal insufficiency, end stage renal disease, severe heart failure, and adrenal insufficiency. Elderly individuals are at increased risk of hyperkalemia because they often have one or more of these conditions or take one or more of the medications that impair potassium excretion.

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