The ascending colon and portions of the transverse colon are perfused by branches of the superior mesenteric artery, with the remainder of the colon receiving arterial blood from tributaries of the inferior mesenteric artery. Distal iliac arterial branches perfuse the anal canal. Venous drainage is achieved via the superior and inferior mesenteric veins laying in close proximity to their arterial counterparts and subsequently dumping into the portal vein.

Additional gross morphologic structures include lymphatic vessels, in close approximation to the vasculature, leading to lymph nodes in the celiac, superior, and inferior preaortic regions. Perianal drainage is via the inguinal lymph nodes.

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