Vitamin C

There are no published RCTs of vitamin C alone in primary prevention, but data from the small number of trials of vitamin C in combination with other nutrients have not provided any support for a role for high-dose vitamin C supplementation in cancer prevention (Table 3). The Linxian trial found no significant effect of supplementing Chinese men and women with 120 mg vitamin C and 30 mg molybdenum daily for 5 years on the risk of cancers of the oesophagus or stomach. The Polyp Prevention Study, a trial of 864 patients with previous

Table 4 Summary of large intervention trials (>1000 subjects) investigating the role of antioxidants and cancer in secondary prevention3

Trial Characteristics Sex Length of Treatment Effect of antioxidant of subjects follow-up (years) supplementation

Table 4 Summary of large intervention trials (>1000 subjects) investigating the role of antioxidants and cancer in secondary prevention3

Trial Characteristics Sex Length of Treatment Effect of antioxidant of subjects follow-up (years) supplementation

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