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From the Food and Nutrition Board, Council, Institute of Medicine.

US National Research

From the Food and Nutrition Board, Council, Institute of Medicine.

US National Research detected should be conducted. This is typically done first with animal models, followed by human clinical trials or metabolic studies, which include at least one level of intake at which effects of inadequacy are observed and can be linked directly to the nutrient under study. Frequently, it is not possible to remove or add some nutrients to a diet without altering the content of other nutrients; this is particularly true for energy-yielding nutrients, such as omega-3 fatty acids, or substances such as fiber. This makes the interpretation of the resulting data less clear.

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