Zollinger-Ellison Syndrome (ZES) refers to the triad of severe ulcer disease, gastric acid hypersecretion, and non-beta islet cell tumors of the pancreas. These tumors release gastrin, a very potent stimulatory secretagogue; hence, they are referred to as gastrinomas. ZES is thought to be responsible for 1% of all duodenal ulcers. The most common presentation is that of a single duodenal ulcer that is persistent and progressive, and is less responsive to the usual therapy. Increased serum gastrin concentrations are a hallmark of ZES. Reducing gastric acid secretion via antisecretory agents is valuable in the medical management of patients with ZES while the patient is stabilized or being evaluated for definitive treatment. Surgery is the treatment of choice for the gastrinomas; successful resection of gastrinomas ranges from 20 to 45% of patients. Five-year survival rates for all patients with gastrinomas range between 60 and 75%.
See also: Cancer: Epidemiology of Gastrointestinal Cancers Other Than Colorectal Cancers. Microbiota of the Intestine: Prebiotics. Stomach: Structure and Function.
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