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fibroblasts

TNF-a

Neutrophils

Similar to IL-1a and ß

Figure 7-5 Female patient with chest wall wound after radiation (left breast removed due to breast cancer).

Radiotherapy

Acute effects of radiation on tissues include stasis and occlusion of small blood vessels. In addition, there is a direct effect of radiation on fibroblast proliferation leading to both decreased collagen production and decreased wound tensile strength.11 Radiation may lead to chronic, nonhealing wounds with a potentially devastating impact for the patient (Fig. 7-5).

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